Fetus in the womb, computer artwork.

Enlarge / Fetus in the womb, computer artwork. (credit: Science Photo Library – SCIEPRO)

The placenta supports the fetus while it is in utero (and, according to some, can support a rosebush if it is buried after delivery).We know it’s essential for a successful pregnancy, but we don’t really know exactly how it works because we’ve had no experimental models we can use to study it. Until now.

Researchers in England examined all of the signaling molecules they could find rushing around between the mother and the placenta (which originates from fetal tissue), figuring they might induce the placenta to grow and develop. From this analysis they generated a blend of signaling molecules that they expected could induce placental formation in a culture dish.

They then obtained cells from first trimester placentas from women who had had normal pregnancies but decided to abort. These cells were grown in media that contained the factors identified by this team. Within a week, the cells were growing into organoids—small blobs of tissue similar to organs in mature organisms. The cells seem perfectly happy in this media; at the time this paper was written, they have been stable for a year.

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